Selected Recent Lab Publications

 

 

Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ.

FEBS Lett. 2017 Oct 25. doi: 10.1002/1873-3468.12886. [Epub ahead of print]

PMID: 29067690

 

Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization.

Moreno-Velásquez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00710-17. doi: 10.1128/AAC.00710-17. Print 2017 Oct.

PMID: 28760907

 

A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ.

MBio. 2017 Feb 7;8(1). pii: e02319-16. doi: 10.1128/mBio.02319-16.

PMID: 28174315

 

Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus.

Vargas-Muñiz JM, Renshaw H, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Asfaw Y, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2016 Jun 22;7:997. doi: 10.3389/fmicb.2016.00997. eCollection 2016.

PMID: 27446037

 

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA.

MBio. 2016 Apr 26;7(2):e00492-16. doi: 10.1128/mBio.00492-16.

PMID: 27118592

 

Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis.

Renshaw H, Vargas-Muñiz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ.

Infect Immun. 2016 Apr 22;84(5):1556-64. doi: 10.1128/IAI.01190-15. Print 2016 May.

PMID: 26953327

 

Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.

Juvvadi PR, Pemble CW 4th, Ma Y, Steinbach WJ.

FEBS Lett. 2016 Feb;590(4):501-8. doi: 10.1002/1873-3468.12075. Epub 2016 Feb 15.

PMID: 26864964

 

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.

Falloon K, Juvvadi PR, Richards AD, Vargas-Muñiz JM, Renshaw H, Steinbach WJ.

PLoS One. 2015 Sep 14;10(9):e0137869. doi: 10.1371/journal.pone.0137869. eCollection 2015.

PMID: 26366742

 

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.

Juvvadi PR, Muñoz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4946-55. doi: 10.1128/AAC.00263-15. Epub 2015 Jun 8.

PMID: 26055379

 

The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.

Vargas-Muñiz JM, Renshaw H, Richards AD, Lamoth F, Soderblom EJ, Moseley MA, Juvvadi PR, Steinbach WJ.

Fungal Genet Biol. 2015 Aug;81:41-51. doi: 10.1016/j.fgb.2015.05.014. Epub 2015 Jun 5.

PMID: 26051489

 

Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Steinbach WJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4727-33. doi: 10.1128/AAC.00946-15. Epub 2015 May 26.

PMID: 26014950

Our lab has published over 80 scientific articles, including 4 cover articles on various aspects of fungal molecular pathogenesis.  Our publications encompass a broad area of fungal disease and translational science. A brief and recent collection is listed here.

Duke University Medical Center

Department of Pediatrics - Infectious Diseases
Department of Molecular Genetics & Microbiology

 

427 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710 | Tel: 919 681 2613  

Steinbach Lab